Spyre Therapeutics, Inc.
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Key market data
Analyst consensus
18 analysts covering SYREAnalyst Price Target Disagreement for Spyre Therapeutics, Inc.
Wall Street's bull case implies +51% from the current price; the bear case implies +13%. A 38% spread signals high analyst disagreement — run your own DCF to anchor on fundamentals rather than street consensus.
Ownership & short interest
Insider Trading Activity for SYRE
| Insider | Role | Type | Shares | Price | Value | Date | Filing |
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About Spyre Therapeutics, Inc.
Spyre Therapeutics, Inc., a clinical stage biotechnology company, focuses on developing therapeutics for patients living with inflammatory bowel disease (IBD) and rheumatic diseases. The company develops SPY001, a humanized monoclonal immunoglobulin G1 antibody that is in phase-2 clinical stage designed to bind selectively to the a4ß7 integrin being developed for the treatment of IBD (ulcerative colitis and Crohn's disease); and SPY002 and SPY072 anti-TL1A mAbs designed to bind to tumor necrosis factor-like ligand 1A (TL1A). It is also developing SPY003, a clinical-stage program, which is in phase-2 clinical stage designed to bind to interleukin 23 (IL-23); SPY120, a combination of anti-a4…
SYRE — frequently asked
Is SYRE a buy right now?
Wall Street's consensus rating on Spyre Therapeutics, Inc. is Strong Buy across 18 analysts, with a mean price target of $119.93 (+40% vs. the current $85.90). Ratings are a starting point — run the DCF and check the financial-health readings above before deciding.
When is SYRE's next earnings date?
Spyre Therapeutics, Inc. is next scheduled to report earnings around Nov 3, 2026. A full SYRE research report from Basis Report covers the setup into that print — estimates, the beat/miss record, and what would move the thesis.
What is the analyst price target disagreement for Spyre Therapeutics, Inc.?
Analysts covering Spyre Therapeutics, Inc. (SYRE) range from a bear-case target of $97.00 to a bull-case high of $130.00, with a mean consensus target of $119.93 across 15 analysts. The spread of $33.00 (38% of the current price) indicates high disagreement on the outlook. Run the DCF calculator to build your own estimate independent of street consensus.
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